Taking VONJO

Taking a daily treatment plan tailored to your type of myelofibrosis (MF)

VONJO is taken twice each day.

For VONJO, the recommended starting dose is two 100 mg capsules, which are taken twice each day (BID)—with or without food. VONJO capsules should be swallowed whole, not chewed, opened, or broken into smaller pieces. You should take VONJO at the same time every day, exactly as your doctor tells you to take it.

Following your doctor’s prescription from the start is an important part of your VONJO daily treatment plan. Do not change your dose or stop taking VONJO without talking with your doctor.

Vonjo dosing instructions
VONJO dosing instructions

Tips for following your plan

If you accidentally take too much VONJO, tell your doctor or take your bottle of VONJO to the nearest emergency room right away.
If you miss a dose of VONJO, skip the dose and just take your next dose at your regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose.
Once you start VONJO, continue taking it every day for as long as your doctor prescribes it. Everyone responds to treatment differently, and your doctor will monitor how you react to VONJO.

Keeping track of your treatment

Throughout treatment, your doctor may run some tests before and during treatment with VONJO (as needed).

A complete blood count (CBC) helps track how you’re responding to treatment, and if there are changes in your blood cell counts that you need to discuss

Coagulation testing will check your risk of bleeding problems or blood clotting issues before you start taking VONJO

A baseline electrocardiogram (ECG) will check the electrical activity of your heart

Managing possible side effects

Whenever you talk with your doctor about taking any medication, you should discuss possible side effects and how to manage them throughout treatment.

With VONJO, the most common side effects include: diarrhea; nausea; vomiting; low platelet counts (thrombocytopenia); low red blood cell counts (anemia); and swelling of your ankles, legs, and feet. If you develop any of these symptoms, your doctor will tell you what to do. If you notice any change in how often you have bowel movements, if they become softer or you have diarrhea, start taking an antidiarrheal medicine (eg, loperamide) as soon as you notice changes, as directed by your doctor.

Take antidiarrheal medicine
(as directed by your doctor)
Drink fluids

Diarrhea can cause loss of too much body fluid (dehydration), so be sure to tell your doctor if you have it and follow instructions for how to treat it. Drink plenty of fluids to help prevent dehydration. In addition, you will be instructed on how to manage nausea and vomiting if it occurs during treatment, but be sure to tell your doctor if it becomes severe.

Tell your doctor right away if you develop any of the symptoms listed in the Prescribing Information, such as:

  • Unusual bleeding, bruising, and fever
  • Feeling dizzy, lightheaded, or faint
  • Severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • Pain or discomfort in your arms, back, neck, jaw, or stomach
  • Weakness in one part or on one side of your body
  • Swelling, pain, or tenderness in one or both legs
  • Shortness of breath or difficulty breathing
  • Chills, aches, painful skin rash, or blisters

These are not all the possible side effects with VONJO. Call your doctor for medical advice.

You’re not on this journey alone. Start with a map to help you stay on track.

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Download a guide for tips on how to have ongoing chats with your doctor about VONJO and managing your MF.

Stay connected with your healthcare team throughout treatment with VONJO, so they can help you follow your treatment plan.